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Marine Anticancer Drugs In silico study of cytotoxic secondary metabolites obtained from marine derived fungi

Marine Anticancer Drugs In silico study of cytotoxic secondary metabolites obtained from marine derived fungi

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Marine derived fungi have shown in recent years to produce a plethora of new bioactive secondary metabolites with biological activities mainly focused in the areas of antibiotic and anticancer properties.There lies immense scope of exploring marine fungus to obtain antitumor leads and drugs. In this study, we have taken seven secondary metabolites obtained from marine derived fungi that are experimentally proven to be cytotoxic against various human/cancer cell lines. But the biological targets and mechanism of action (MOA) of these compounds are not elucidated till date because of various technological and economic hindrances. Using Pharmmapper – a web server for…

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Description

Marine derived fungi have shown in recent years to produce a plethora of new bioactive secondary metabolites with biological activities mainly focused in the areas of antibiotic and anticancer properties.There lies immense scope of exploring marine fungus to obtain antitumor leads and drugs. In this study, we have taken seven secondary metabolites obtained from marine derived fungi that are experimentally proven to be cytotoxic against various human/cancer cell lines. But the biological targets and mechanism of action (MOA) of these compounds are not elucidated till date because of various technological and economic hindrances. Using Pharmmapper – a web server for drug target identification, we found the potential antitumor targets of these compounds and determined their cancer relevance later.Further molecular docking studies and binding site predictions were performed to predict the affinity and binding sites of the cytotoxic compounds with their potential targets.This study indicates the importance of cytotoxic secondary metabolites from marine fungi in regards to their use as antitumor agents.

Langue
en
Version
Broché
Date de sortie initiale
08 octobre 2014
Nombre de pages
72
Illustrations
Avec illustrations

Personnes impliquées

Auteur principal

Ahmed Madiha

Deuxième auteur

D B M Virupakshaiah

Editeur principal

Lap Lambert Academic Publishing

Informations sur le fabricant

Nom du fabricant
OmniScriptum SRL
Adresse du fabricant
Str. Armeneasca 28/1, office 1 | 2012| Chisinau| MD
Adresse électronique du fabricant
info@omniscriptum.com

Autres spécifications

Hauteur de l’emballage
4 mm
Hauteur du produit
4 mm
Largeur d’emballage
152 mm
Largeur du produit
152 mm
Livre d‘étude
Non
Longueur d’emballage
229 mm
Longueur du produit
229 mm
Poids de l’emballage
118 g
Police de caractères extra large
Non

EAN

EAN
9783659610561

Sécurité des produits

Opérateur économique responsable dans l’UE

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Catégories

Ordinateurs et Informatique

Informatique

Livres

Livre, ebook ou livre audio ?

Livre

Disponibilité

Disponible à l’adresse suivante

Langue

Anglais

Type de livre

Paperback

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