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New Mechanism for Antibiotic Resistance ynfA, A Novel Escherichia Coli Gene of the Small Multidrug Resistance Superfamily

New Mechanism for Antibiotic Resistance ynfA, A Novel Escherichia Coli Gene of the Small Multidrug Resistance Superfamily

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ynfA, of Escherichia coli (P76169 swissprot, g1787865 GenBank) is the newest member of the Small Multidrug Resistance (SMR) gene family. It was identified with the aid of bioinformatics tools that allowed us to follow evolutionary principles of sequence conservation, in which functional similarity is inferred from sequence similarity, but surprisingly biochemical data yielded an unexpected mode of action for YnfA. The SMR gene family represents a prokaryotic transport system that is restricted to the eubacterial kingdom and has been so far identified in 63 bacterial species in both gram-negative and -positive bacterial species. Members of this family are composed of…

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SKU: RICSIVP0388177740858
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Description

ynfA, of Escherichia coli (P76169 swissprot, g1787865 GenBank) is the newest member of the Small Multidrug Resistance (SMR) gene family. It was identified with the aid of bioinformatics tools that allowed us to follow evolutionary principles of sequence conservation, in which functional similarity is inferred from sequence similarity, but surprisingly biochemical data yielded an unexpected mode of action for YnfA. The SMR gene family represents a prokaryotic transport system that is restricted to the eubacterial kingdom and has been so far identified in 63 bacterial species in both gram-negative and -positive bacterial species. Members of this family are composed of 100-120 amino acid residues in length and span the membrane four times as ¿-helices. A ynfA inframe deletion mutant was created from an isogenic wild type E. coli MG1655 that displayed no growth defect compared to its wild type isogenic pair. Thus the mutant displayed antibiotic resistance.

Langue
en
Version
Broché
Date de sortie initiale
13 février 2012
Nombre de pages
80
Illustrations
Non

Personnes impliquées

Auteur principal

Nir Hus

Editeur principal

Lap Lambert Academic Publishing

Informations sur le fabricant

Nom du fabricant
OmniScriptum SRL
Adresse du fabricant
Str. Armeneasca 28/1, office 1 | 2012| Chisinau| MD
Adresse électronique du fabricant
info@omniscriptum.com

Autres spécifications

Hauteur de l’emballage
5 mm
Largeur d’emballage
152 mm
Longueur d’emballage
229 mm
Poids de l’emballage
127 g
Police de caractères extra large
Non

EAN

EAN
9783847317807

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Catégories

Science et nature

Biologie

Livres

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Livre

Disponibilité

Disponible à l’adresse suivante

Langue

Anglais

Type de livre

Paperback

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